Experimental production of palatal carcinoma by local application of 9, 10-dimethyl-1, 2-benzanthracene

Metabolic and carcinogenic studies with 9, 10-dimethyl-1, 2-benzanthracene.

Emulsions Containing 9,1O-Dimethyl-1, 2-Benzanthracene

Emulsions of fat suitable for intravenous ad ministration have been used in this laboratory as @ source of calories, as an aid in the study of lipid metabolism, and as a vehicle for fat-soluble ma tenials. The latter use has been of value in studies with rats on the effects of the intravenous injection Cof carcinogenic hydrocarbons. Several investiga tions have been reported in which emulsions ...

Effect of dose and hormones on tumor production in rats given emulsified 9, 10-dimethyl-1,2-benzanthracene intravenously.

Intravenously administered oil emulsions which contain 9,10-dimethyl-l,2-benzanthracene have been shown previously to produce a fairly high in cidence of mammary tumors in female rats (5). Male rats, however, developed few tumors, and these were chiefly papillomas arising from the se baceous gland ducts of external ears. During these and subsequent studies it became apparent that tumor incidenc...

A Transplantable 9, 10-Dimethyl-1,2-Benzanthracene Sarcoma in the Syrian Hamster*

Comparatively little has been published on the use of the hamster in cancer research and only two reports, including some 15 instances, of spontaneous tumors are available (1, 9). The earliest experimental work appears to be Gye and Fould's (9) production of a mixed-cell sarcoma in two males by injecting 3,4-benzpyrene, in 1939. A year later Halberstaedter (11) reported the production of a simi...

9, 10-Dimethyl-1,2-Benzanthracene as a Highly Potent Carcinogen for the Rabbit's Skin*

There are many types of investigation connected with the tumor problem for which a large laboratory animal such as the rabbit would be more useful than a small one such as the mouse. For problems connected with experimental carcinogenesis the limiting factor is, naturally, the availability of a suitable carcinogen. Neither tar nor 3,4-benzpyrene can be considered as suitable for the rabbit: The...